Manager, QC Studies (Gene Therapy Program)

Manager, QC Studies (Gene Therapy Program)

University Overview

The University of
Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This
historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12
highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s
distinctive interdisciplinary approach to scholarship and learning. As an employer Penn has been ranked nationally on many occasions with
the most recent award from Forbes who named Penn one of America’s Best Employers By State in 2021.

Penn offers a unique working
environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of
educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide
variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive
benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a
wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and
resources, and much more.

COVID-19 vaccination is a requirement for all positions at the University of Pennsylvania. New hires are
expected to be fully vaccinated before beginning work at the University. For more information about Penn’s vaccine requirements and the use
of Penn Open Pass, visit the Penn
COVID-19 Response website
for the latest information.

Posted Job Title
Manager, QC Studies (Gene Therapy

Job Profile Title
Manager D

Job Description Summary
The Gene Therapy Program (GTP)
is entering a new era of unprecedented opportunity with the great potential to reshape the face of medicine as we know it. Our discoveries
have set the stage for successful treatments and possibly even cures for devastating genetic diseases.

The laboratory of Dr. Jim
Wilson, at GTP of the University of Pennsylvania, has been a leader in the development of innovative vector technology for close to three
decades. We have emerged as the “go-to” organization for public and private partners, who want to participate in the gene therapy space.
Currently, we are positioned to lead another round of vector innovation and establish pre-clinical and clinical proof-of-concept in
therapeutic applications of in-vivo genome editing.

Continuation of all GTP positions is contingent upon funding.


Our Vector Core is a state-of-the-art facility which provides vector-related materials and services in support of
basic and translational research worldwide, producing vectors in support of IND-enabling research, conduct GLP assays, oversee CMO’s in
vector production and is expanding to conduct state-of-the art process development.

Due to continued growth of our program, we are
searching for a Manager of Quality Control Studies (MQCS) to lead drug product, stability, and biodistribution for IND-enabling

As the Manager, you manage and direct the activities of the Quality Control Studies Sample management teams. You will
partner with the Director of GLP QC and Associate Director of Assay Development to design and implementation of drug product, stability, and
biodistribution studies for AAV vectors. You will design and implement training modules for biodistribution studies, providing training to
GTP staff and maintain compliance tracking. You will manage the reagents used and partner with QA closely to effectively execute these
studies as well as archiving samples.

As a successful candidate, you will have experience in drug product, stability, and
biodistribution studies under GLP conditions for biologic therapies.


  • Bachelor’s Degree and 5 to 7 years
    of applicable experience preferably in the pharmaceutical industry, or an equivalent combination of education and experience is
  • Supervisory experience preferred.
  • Extensive knowledge of cell-based and molecular assays
  • Understanding of GLP regulatory standards preferred.
  • Self-starter but also a strong desire to contribute and work
    collaboratively to achieve goals.
  • Success in roles requiring execution of multiple tasks while responding to multiple
  • Highly functioning, detail-oriented, and analytical candidate.
  • Excellent oral/written communication skills

Job Location – City, State
Philadelphia, Pennsylvania

Department /

Perelman School of Medicine

Pay Range
$59,703.00 – $95,524.33

Affirmative Action

Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender
identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected

Special Requirements
Background check required after a conditional job offer is made. Consideration of the
background check will be tailored to the requirements of the job.

University Benefits

  • Health, Life, and
    Flexible Spending Accounts
    : Penn offers comprehensive medical, prescription, behavioral health, dental, vision, and life insurance
    benefits to protect you and your family’s health and welfare. You can also use flexible spending accounts to pay for eligible health care
    and dependent care expenses with pre-tax dollars.
  • Tuition: Take advantage of Penn’s exceptional tuition benefits. You, your
    spouse, and your dependent children can get tuition assistance here at Penn. Your dependent children are also eligible for tuition
    assistance at other institutions.
  • Retirement: Penn offers generous retirement plans to help you save for your future. Penn’s
    Basic, Matching, and Supplemental retirement plans allow you to save for retirement on a pre-tax or Roth basis. Choose from a wide variety
    of investment options through TIAA and Vanguard.
  • Time Away from Work: Penn provides you with a substantial amount of time
    away from work during the course of the year. This allows you to relax, take vacations, attend to personal affairs, recover from illness or
    injury, spend time with family-whatever your personal needs may be.
  • Long-Term Care Insurance: In partnership with Genworth
    Financial, Penn offers faculty and staff (and your eligible family members) long-term care insurance to help you cover some of the costs of
    long-term care services received at home, in the community or in a nursing facility. If you apply when you’re newly hired, you won’t have to
    provide proof of good health or be subject to underwriting requirements. Eligible family members must always provide proof of good health
    and are subject to underwriting.
  • Wellness and Work-life Resources: Penn is committed to supporting our faculty and staff as
    they balance the competing demands of work and personal life. That’s why we offer a wide variety of programs and resources to help you care
    for your health, your family, and your work-life balance.
  • Professional and Personal Development: Penn provides an array of
    resources to help you advance yourself personally and professionally.
  • University Resources: As a member of the Penn
    community, you have access to a wide range of University resources as well as cultural and recreational activities. Take advantage of the
    University’s libraries and athletic facilities, or visit our arboretum and art galleries. There’s always something going on at Penn, whether
    it’s a new exhibit at the Penn Museum, the latest music or theater presentation at the Annenberg Center, or the Penn Relays at Franklin
    Field to name just a few examples. As a member of the Penn community, you’re right in the middle of the excitement-and you and your family
    can enjoy many of these activities for free.
  • Discounts and Special Services: From arts and entertainment to transportation
    and mortgages, you’ll find great deals for University faculty and staff. Not only do Penn arts and cultural centers and museums offer free
    and discounted admission and memberships to faculty and staff. You can also enjoy substantial savings on other goods and services such as
    new cars from Ford and General Motors, cellular phone service plans, movie tickets, and admission to theme parks.
  • Flexible Work
    Flexible work options offer creative approaches for completing work while promoting balance between work and personal
    commitments. These approaches involve use of non-traditional work hours, locations, and/or job structures.
  • Penn Home Ownership
    Penn offers a forgivable loan for eligible employees interested in buying a home or currently residing in West Philadelphia,
    which can be used for closing costs or home improvements.
  • Adoption Assistance: Penn will reimburse eligible employees on
    qualified expenses in connection with the legal adoption of an eligible child, such as travel or court fees, for up to two adoptions in your

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