Metabolism and the natural bodily aging process are inextricably linked. As each of us continues to blow out birthday lights and get a little older each year, our metabolism slows down just a little bit more. When this happens, it usually becomes much easier to put on weight and much harder to add muscle.
In many ways, it is not easy to say that the deterioration of metabolic health is literally the aging process that is set in motion. People with poor metabolic health, especially as they get older, are more prone to a wide range of conditions, including diabetes, heart disease, obesity and stroke. To put it briefly, your metabolism largely determines the true “age” of your body, regardless of the date on your driver’s license. Previous research even goes so far as to conclude that obesity (an important indicator of poor metabolic health) has essentially the exact same effect on the body and its cells as for premature aging processes. (Though to be fair, high blood pressure or sugar, as well as too much HDL cholesterol, is also associated with metabolic health.)
So what is the best way to promote bodily life and strong metabolic health? A groundbreaking new study published in Cell metabolism compared the effect of diet versus three different drugs believed to have anti-aging qualities on metabolic health and cell function.
Read on to learn exactly what the research team revealed about what is most powerful in combating aging. So do not miss 3 great secrets to Living to 99, according to Betty White.
Carried out at the University of Sydney’s Charles Perkins Center, this preclinical research project concludes that diet / nutrition is much more beneficial in terms of both anti-aging and the promotion of good metabolic health compared to three drugs that are usually prescribed to either treat diabetes or slow aging. .
The study even indicates that the substances actually appear to “dampen” or mitigate the body’s reactions to various combinations of proteins, fats and carbohydrates.
“Diet is a powerful drug. But at the moment, drugs are administered without consideration of whether and how they can interact with our diet composition – even when these drugs are designed to work in the same way and in the same nutrient signaling pathways as diet.” study author and academic director of the Charles Perkins Center, Professor Stephen Simpson.
These results are of a preliminary nature and require further research. Still, study authors say their work provides a compelling argument that the right diet can help prevent or at least “keep in check” various conditions associated with advanced age and poor metabolic health, including diabetes, stroke and heart disease. much more effective than medication.
“We discovered the diet composition had a far more powerful effect than drugs, which largely dampened dietary responses rather than reshaped them,” Simpson adds.
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The aim of the project was to determine whether drugs or diet have a greater impact on nutrient perception and various other metabolic pathways. In addition, researchers sat down to answer whether diet or medication interact with each other and increase or decrease efficiency from a metabolic perspective.
The three drugs studied in this study were metformin, rapamycin, and resveratrol. As many as 40 different combinations of proteins, carbohydrates, fats, calories and drugs were administered to a group of mice.
“Given that humans share essentially the same nutrient signaling pathways as mice, research suggests that humans would benefit from changing their diet to improve metabolic health instead of taking the drugs we studied,” comments Simpson. .
After administering the doses, the researchers focused heavily on the rodents’ liver, as the organ plays a major role in metabolism regulation.
Another reason why this research is particularly remarkable was the use of the geometric framework of nutrition by scientists, which focuses on combinations of nutrients as opposed to individual nutrients. This allowed study authors to assess the cumulative impact of proteins, fats, and more on aging processes rather than just protein or fat individually.
Related: The best foods to slow aging after 50, say dietitians
Sure enough, both calorie intake and nutrient levels / combinations (proteins, carbohydrates) had a strong influence on the liver.
It is noteworthy that diet also had a major impact on cell function in general. Protein intake levels affected the activity of the cell’s mitochondria, which is where the cells create energy. Cellular energy is incredibly important as the energy level determines how efficiently cells function and ultimately create new cells. New cell development and overall cellular function are strongly associated with the bodily aging process. This observation suggests that diet goes a long way toward keeping the body’s cells “young” and full of energy.
All in all, research strongly suggests that a healthy, balanced diet is great for both the liver (a central metabolic organ) and cell health (an essential aspect of the aging process) and offers more anti-aging benefits than the three drugs tested.
“This approach is the only way we can get an overview of the interplay between diet, our health and physiology,” notes lead study author Professor David Le Couteur of the Charles Perkins Center and Faculty of Medicine and Health.
“We all know what we eat affects our health, but this study showed how food can affect many of the processes that operate in our cells dramatically. This gives us insight into how diet affects health and aging,” he concludes. .
For more, check out the # 1 best way to stay healthy in old age, says new study.
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